Valsartan CAS no 137862-53-4

$1 - 100 /Gram

Min. Order:

1 Gram

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Valsartan is a specific angiotensin II (AT1) receptor antagonist, and it is also another non-skin AT1 receptor antagonist used clinically after Losartan. It regulates systemic blood pressure and maintains electrolytes and body fluids. The balance aspect plays a key role. It selectively acts on the AT1 receptor subtype and blocks the binding of AngⅡ to the AT1 receptor (its specific antagonistic effect on the AT1 receptor is about 20,000 times greater than that of the AT2 receptor), thereby inhibiting vasoconstriction and the release of aldosterone. Antihypertensive effect, but does not inhibit the release of aldosterone caused by potassium ions (K+). The antihypertensive effect is better than enalapril. It is suitable for the treatment of antihypertensive, mild to moderate primary hypertension, especially for secondary hypertension caused by kidney damage, which can significantly reduce the high blood pressure associated with diabetes or normal renal function. Proteinuria in patients with blood pressure, and has a renal protective effect to promote the excretion of uric acid and urinary sodium. It is also suitable for reducing cardiovascular mortality in high-risk patients (left ventricular failure or left ventricular dysfunction) after a heart attack.

Product Categories : API Intermediates > Valsartan Intermediate

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