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Clotrimazole is a synthetic pyrrole antifungal drug, which has inhibitory effect on a variety of pathogenic fungi. It can also have a bactericidal effect when the concentration is high. Clotrimazole inhibits the biosynthesis of fungal ergosterol and other sterols by interfering with the activity of cytochrome P450; damages the fungal cell membrane and changes its permeability, causing the loss of important substances in the cell; it can also inhibit fungal triglycerides and phospholipids The biosynthesis; this product can still inhibit the activity of oxidation and peroxidase, causing excessive accumulation of peroxide in the cell, causing degeneration and necrosis of the fungal subcellular structure. Clotrimazole has a broad-spectrum antifungal activity. It has a good antibacterial effect against Epidermophyton, Trichophyton, Aspergillus, Pigmentation fungus, Cryptococcus and Candida, and has good antibacterial effect against Sporothrix schenckii and dermatitis blastomycetes. , Coccidioides spp., Histoplasma spp., etc. also have certain antibacterial activity. Clotrimazole has a good antibacterial effect against Candida, Cryptococcus, Aspergillus, Algae, Dermatophytes, etc. in vivo and in vitro. The curative effect of mycosis is similar to that of amphotericin B. It has a good effect on visceral pathogenic fungi such as Candida albicans, Cryptococcus neoformans, coccidioides and histoplasma, etc. It has a better effect on Candida albicans than nystatin. powerful. Fungi are not easy to develop resistance to this product.
Product Clotrimazole
CAS 23593-75-1
MF C22H17ClN2
MW 344.84
Product Categories : API Intermediates > Clotrimazole Intermediate
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